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Page Title:

Immune Cell Dynamics Across Human Diseases _ A Systematic Review and Meta_Analysis



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Abstract

Background _ The orchestration of innate and adaptive immune responses underpins disease pathogenesis, progression, and therapeutic response in a wide spectrum of human disorders.


Methods _ We systematically searched PubMed, EMBASE, Cochrane CENTRAL, Web of Science, and Scopus (January_1990_June_2023) for studies reporting quantitative immune cell phenotypes in patients versus healthy controls or longitudinally during treatment.
Risk of bias was assessed with the Joanna Briggs Institute critical appraisal tool; data were pooled using random_effects meta_analysis.

Results _ 1,342 records yielded 248 eligible articles encompassing 62,456 participants across 48 disease categories (autoimmune, infectious, neoplastic, cardiovascular, neurodegenerative). Me
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